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Rotavirus Vaccine In NICUs Does Not Lead To Outbreaks, Study Shows

Rotavirus vaccines do not cause significant outbreaks of the disease in neonatal intensive care units (NICUs), according to a new national study. The research will be presented at the Pediatric Academic Societies (PAS) 2024 Meeting, held May 3-6 in Toronto. 

The findings are important, study authors say, because many NICUs avoid vaccinating against rotavirus due to a theoretical risk of transmission, yet some infants are too old to receive the vaccine once discharged from the NICU. The study conducted at Children's Hospital of Philadelphia evaluated the risk of vaccinated patients transferring rotavirus to unvaccinated patients in NICUs that administer the vaccine.

According to researchers, preterm infants are at higher risk of the highly contagious but preventable virus, yet few receive the vaccine in hospital settings. The rotavirus vaccine contains a weakened form of the virus to produce a stronger immune response.

The study found that 99.3% of non-vaccinated patients exposed to vaccinated patients did not test positive for the disease. Non-vaccinated patients that contracted rotavirus had no symptoms after 14 days, according to the study.

Immunization with rotavirus vaccine has been standard practice in the Children's Hospital of Philadelphia NICU since 2007, and the safety of this practice was supported by retrospective clinical data published in Pediatrics in 2014 – however this remains an uncommon practice in NICUs across the United States. Our yearlong, prospective study done in collaboration with the Centers for Disease Control and Prevention suggests that benefits of vaccinating NICU patients against rotavirus outweigh risks. Inpatient vaccination allows protection of a vulnerable population against a common, preventable cause of severe diarrheal illness."

Kathleen Gibbs, MD, study's lead neonatologist from Children's Hospital of Philadelphia

The study analyzed 3,448 weekly stool samples from 774 patients between January 2021-January 2022.


Covid Vaccine Side Effects: 4 Takeaways From Our Investigation

Soon after their arrival in late December 2020, the Covid-19 vaccines turned the pandemic around and opened a path back to normalcy. They prevented about 14.4 million deaths worldwide, according to one estimate.

In a small percentage of people, they also produced side effects.

Over the course of more than a year, The New York Times talked to 30 people who said they had been harmed by Covid vaccines. Their symptoms may turn out to be unrelated to the shots. But they — along with more than a dozen experts — felt federal officials are not doing enough to investigate their complaints.

All vaccines carry some risk of side effects. More than 270 million Americans received about 677 million doses of the Covid vaccines, and even rare side effects — occurring, say, in just 0.001 percent of patients — might mean thousands of recipients were affected.

Indeed, more than 13,000 have submitted claims to a government fund that compensates people for Covid vaccine injuries. So far, however, only a dozen people have been compensated, nearly all of them for a heart problem caused by the vaccines.

Here are four takeaways from our investigation.

Even the best vaccines and drugs have some side effects. That does not negate their benefits, nor does it suggest that people should stop taking them.

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Safety Of Rotavirus Vaccinations In NICU Babies

Providing rotavirus vaccine to infants in neonatal intensive care units (NICUs) is safe and does not lead to disease outbreaks (1✔ ✔Trusted SourceRotavirus vaccination not tied to NICU outbreaks, researchers sayGo to source). Rotaviruses are majorly responsible for diarrheal disease among infants and young children. The vaccine, which contains a weakened form of the virus to produce a stronger immune response, is administered via drops. '#Rotavirusvaccinations are deemed safe for infants in neonatal intensive care units (NICUs), with no associated disease outbreaks reported. #vaccinesforchildren #rotavirus #ICU' Researchers from the Children's Hospital of Philadelphia, US noted that preterm infants, usually kept in the NICU, are at higher risk of the highly contagious but preventable virus, yet few receive the vaccine over transmission fears. To understand, the team conducted an analysis of 3,448 weekly stool samples from 774 patients between January 2021 and January 2022.

They found that "99.3 per cent of non-vaccinated patients exposed to vaccinated patients did not test positive for the disease. Non-vaccinated patients that contracted rotavirus had no symptoms after 14 days."

"Our yearlong, prospective study done in collaboration with the US Centers for Disease Control and Prevention (CDC) suggests that the benefits of vaccinating NICU patients against rotavirus outweigh the risks," said Kathleen Gibbs, MD, the study's lead neonatologist from Children's Hospital of Philadelphia.

"In-patient vaccination allows protection of a vulnerable population against a common, preventable cause of severe diarrheal illness," she added.

The findings are important because many NICUs avoid vaccinating against rotavirus due to a theoretical risk of transmission, yet some infants are too old to receive the vaccine once discharged from the NICU.

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According to the CDC guidelines, the first dose must be administered before 15 weeks of age. The study findings will be presented at the ongoing Pediatric Academic Societies (PAS) 2024 Meeting, being held in Toronto, Canada.

Reference:

  • Rotavirus vaccination not tied to NICU outbreaks, researchers say - (https://www.Cidrap.Umn.Edu/rotavirus/rotavirus-vaccination-not-tied-nicu-outbreaks-researchers-say)
  • Source-IANS




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